Injuries to key players remain an issue at many positions for the 49ers. Preparation for Week 9 will bring about a mixed bag of updates on that front. 
Brandon Aiyuk continues to rehab the ACL and MCL tears which ended his 2024 campaign. While progress is being made in his recovery, San Francisco’s top wideout will not take part in practice this week. That decision will further delay the point at which Aiyuk’s 21-day activation window will be opened.
“I think it’s week-to-week from here on out that he has got a chance,” head coach Kyle Shanahan said of Aiyuk (via Matt Maiocco of NBC Sports Area). “It would’ve surprised me if it was this week, but that was just me saying that every week I think he’s getting closer to having a chance. Just not this week.”
Shanahan recently opened the door to Aiyuk suiting up for practice this week, but that will not take place. A return in November is instead still the goal in this case. Provided the 27-year-old can return to full strength relatively soon, his presence will be welcomed on a 49ers offense which has dealt with injuries under center and at the skill positions all season. Along the offensive line, meanwhile, a notable return is imminent.
The 49ers will designate left guard Ben Bartch for return this week, as noted by The Athletic’s Matt Barrows. Bartch has been on injured reserve since mid-September due to a high ankle sprain. Beginning tomorrow, though, his practice window will open. That will leave the 49ers with three weeks to activate Bartch.
The former fourth-rounder has started just four of his appearances with the 49ers, but that total will likely increase once Bartch is activated. He opened the season as San Francisco’s starter at the LG spot vacated by Aaron Banks‘ free agent departure. Provided that remains the case moving forward, Bartch will be counted on to provide stability along the interior of the offensive line. As a pending free agent, his play upon being activated will be key in determining not only the 49ers’ success up front but also his earning potential on the open market next spring.
The 49ers have used two of their eight IR activations for the season so far. Bringing Bartch back into the fold will lower that figure, with the same being true when fellow O-linemen Spencer Burford is activated (which should take place in the near future). Aiyuk resides on the reserve/PUP list, so his return will not count toward the IR activation count; when it will take place nevertheless remains something to monitor closely for the 49ers.